Recent studies have confirmed mounting suspicions of potential links between Alzheimer’s disease and coronary artery disease (CAD). Researchers from Edith Cowan University (ECU) in Australia have uncovered a significant relationship between the neurodegenerative condition and fats in the blood, as well as seven characteristics of heart disease. This discovery highlights the need for further investigation into the genetic links between the two conditions, providing potential targets for understanding the origins of both pathologies.
The research team at ECU delved into large genetic datasets to identify shared genes or gene variations that may increase the risk of Alzheimer’s, CAD, and concentrations of triglycerides and lipoproteins. These fats have been implicated in the development of both Alzheimer’s and heart disease. The study aimed to provide a more detailed understanding of how heart health and brain health are interconnected, shedding light on the complex biological mechanisms underlying both conditions.
While observational evidence has suggested a connection between Alzheimer’s disease and CAD, the genetic analysis conducted by the researchers at ECU revealed that certain shared genes play a role in both conditions. This includes heart disease traits such as angina and heart attacks, as well as increased serum concentrations of lipids like cholesterol and triglycerides. However, the data does not support a causal link between the genetic factors behind Alzheimer’s disease and heart disease. Instead, it suggests that these shared genes may raise the risk of both types of diseases, leading to new biological pathways that can be explored to understand the root causes of Alzheimer’s disease and heart disease.
With an expected 139 million people worldwide projected to have Alzheimer’s by 2050, identifying critical genetic factors, such as the increased risk associated with having two copies of the APOE4 gene, can significantly impact diagnostic methods and potential preventative measures. By uncovering additional triggers for Alzheimer’s and heart disease, researchers hope to pave the way for improved treatments and interventions that could enhance the lives of millions worldwide. Lead author Artika Kirby remains optimistic about the potential impact of these findings on future research and the overall understanding of these complex conditions.